MYP_023310
B1-L-4
Anticancer
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Standard
15 amino acids
C91H151N23O18
Standard
VKRFKKFFSKLKSLV
1855.32 Da
11.39
5.73
5.51
0.3819
-0.08
0.82
-0.17
7.81
90.67
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
703.18
-2.79
26.0
24.0
67.0
132.0
3.0
14.0
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
RECORD: Rec_0008451
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
Huh-7
13.41±1.92 μM
IC50
RECORD: Rec_0143091
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Hemolytic
human red blood cells
>80 μM
HC50
RECORD: Rec_0328980
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
15.20±1.02 μM
IC50
RECORD: Rec_0366714
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
U87
17.91±3.23 μM
IC50