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MYP_023303
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Basic Information
Caerin 1.9 sm(Caerin 1.9 [V13L])
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C125H207N31O29
Standard
Sequence
GLFGVLGSIAKHLLPHVVPVIAEKL
Physicochemical Analysis
2608.17 Da
8.61
0.94
0.63
0.0374
1.13
0.43
0.47
29.32
163.60
0.0400
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
911.07
-2.78
30.0
32.0
83.0
185.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0083769 VERIFIED: YES
Provenance & Taxonomy
Sythetic construct [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID26026377;33008028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0120945 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Caerin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
CD4+ T Lymphocytes
17.5 μM
Cytotoxicity
PMID26026377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0259794 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Caerin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV PsV
PMID26026377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0357691 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Caerin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV Release inhibition
Human immunodeficiency virus (HIV) | T cells
3 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of HIV infection by caerin 1 antimicrobial peptides. | VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA. | Peptides. 2015 Sep;71:296-303. | DOI:10.1016/j.peptides.2015.05.004 | PMID:26026377 PMID26026377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0369145 VERIFIED: YES
Provenance & Taxonomy
Sythetic construct [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human immunodeficiency virus (HIV):inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells
3 μM
IC50
PMID26026377;33008028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/