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MYP_023183
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Basic Information
Trichogin GA IV [G2K] OH
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XKLXGGLXGIL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0188769 VERIFIED: YES
Provenance & Taxonomy
Ascomycetes [Fungus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X=Aib
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25306964/
RECORD: Rec_0214357 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1,4,8
Bio-Activity Profile
Anticancer Cytotoxic
Human epidermoid carcinoma A431
12.5 μM
EC50
PMID15949628;25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949628/
RECORD: Rec_0263446 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1,4,8
Bio-Activity Profile
Hemolytic
human red blood cells
0 % hemolysis at 16 μM
Hemolysis
PMID15949628;25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949628/
RECORD: Rec_0282151 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1,4,8
Bio-Activity Profile
Antimicrobial Antibacterial
Human promyelocytic leukemia HL-60
PMID15949628;25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949628/
RECORD: Rec_0299748 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1,4,8
Bio-Activity Profile
Anticancer Cytotoxic
Human lung carcinoma A549
17.5 μM
EC50
PMID15949628;25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949628/
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