Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2347H3750N608O666S21

DescriptionStandard

        MTLCWWFLLVAFIPMTSGTNPGVKVKLTEKGLEYGRQLGMVSIQQKLKSIKVPDFSGSQTVSPIGNVKYSLSNMCIVSVGLPQSAVNLVQGTGMRLSVSNAFISLRGNWKVKYLHIIKDSGSFDLKVKGLTIGTSIAIKSDETGRPAVSNVNCGATVSSASVKFHGGASWLYNLFRKFIDKALRSAMQKQMCPLVTNAISDLNPQLKTLNVLAKVDQYAEIEYSMVSSPIVSNSSIDFSLKGEFYNIGKHQEPPFSPSAFTLPSQINNMLYIGMSAFTANSAAFVYNKAGALHLFVTDDMVHYPTKLSHPTQHQDIWSLHPIAKRFPGLMMKLLVQTVKPPVTTFEPNNLTVQASSTVTAYAIQPNTTLSPLFVLNLETSVSAQVFVRGMRLAGAVTLNKMTLTLGTSYVGEFQVRSLDSILQLVLKVVVIPRLNVQLAKGYPLPALGKMKLVNTQLEVLKDYMLIGTDVQFTG
    

Molecular Weight51813.92 Da

Isoelectric Point (pI)9.63

Net Charge (pH 7.0)18.16

Net Charge (pH 7.4) 17.38

Charge Density (pH 7.0) 0.0383

GRAVY Index0.16

Hydrophobic Moment 0.85

Boman Index0.15

Instability Index29.69

Aliphatic Index 99.26

Aromaticity 0.0844

Extinction Coeff. Reduced 48360.00

Extinction Coeff. Oxidized 48610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0192876 VERIFIED: NO

Provenance & Taxonomy

OrganismLates calcarifer [Bacterium]

FamilyBPI

Tax ID8187

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence