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MYP_023071
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Basic Information
M-lycotoxin-Hc2a (M-LCTX-Hc2a; Lycotoxin-2; Lycotoxin II; spiders, Arthropods, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
27 amino acids
C149H245N39O35S2
Standard
Sequence
KIKWFKTMKSIAKFIAKEQMKKHLGGE
Physicochemical Analysis
3206.91 Da
10.22
5.85
5.58
0.2167
-0.66
0.68
-0.11
6.69
65.19
0.1111
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1230.70
-6.43
43.0
44.0
118.0
225.0
5.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024570 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli DH5
40 μM
MIC
PMID9442044;18098329 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9442044/
RECORD: Rec_0027366 VERIFIED: NO
Provenance & Taxonomy
Lycosa carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0034790 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli
<10-40 μM
MIC
PaperLycotoxins, Antimicrobial Peptides from Venom of the Wolf Spider Lycosa carolinensis.
RECORD: Rec_0045510 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PMID9442044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9442044/
RECORD: Rec_0047415 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida glabrata.B. thuringiensis subsp. Israelensis
PMID9442044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9442044/
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