Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length477 amino acids

Chemical FormulaC2410H3847N607O668S20

DescriptionStandard

        MFLCGWLVMVTLIPVILSVNPGVEVKITDKGIEYGRQLGIAAIQEKLKKIRIPDFSGKQRVSPIGKVQYSLTNIQIVNIGLPIAPIQLVPGSGVKLSINNAFINLRGNWRVKFLRWVKNSGSFEVGMNDLSISESLAVKSDSTGRPEVSTISCAASVGRVRIKFHGGASWLYNLFSKYIEKALKSALQKQICPLVTNAIDDMNPRLKTLNVLANVDKYAEIEYSMVSSPAISSSSIALKLKGQFYNIGQHQEPPFSAPAFSLPPENSNMLYMALSAFTANSAAFVYHKAGVLSIYITDDMIPKRSPIRLTTTTFGTFIPQISKQFPGLMMKLLMKTDKSPVVTFEPDRVTVQVTGTVTAYAIQPNDTLTPLFILNLDTSVSSKVFLSGMKLGVSLTLNKMKLSLQTSYVGQFQVRTLSNSLEFVLKWVVIPVVNGELLYFPFVPLMCSLKLHLTTMFVLGPKYYDYMLIGTDVKFTG
    

Molecular Weight52654.29 Da

Isoelectric Point (pI)9.62

Net Charge (pH 7.0)18.82

Net Charge (pH 7.4) 18.23

Charge Density (pH 7.0) 0.0394

GRAVY Index0.22

Hydrophobic Moment 0.72

Boman Index0.17

Instability Index36.16

Aliphatic Index 104.15

Aromaticity 0.0943

Extinction Coeff. Reduced 51340.00

Extinction Coeff. Oxidized 51590.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0415030 VERIFIED: NO

Provenance & Taxonomy

OrganismTakifugu rubripes (Japanese pufferfish) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria