Peptide Database

Peptide NameP45(derived from E2 envelope protein of GB virus C)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC83H130N22O31S

DescriptionStandard

        SDRDTVVELSEWGVPCAT
    

Molecular Weight1964.11 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.54

Net Charge (pH 7.4) -3.77

Charge Density (pH 7.0) -0.1968

GRAVY Index-0.21

Hydrophobic Moment 0.38

Boman Index0.02

Instability Index0.01

Aliphatic Index 75.56

Aromaticity 0.0556

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 857.04

LogP -9.85

H-bond Donors 31.0

H-bond Acceptors 29.0

Rotatable Bonds 60.0

Heavy Atoms 137.0

Ring Count 3.0

Amide Bonds 17.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0290675 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1:inhibition of gp41-induced cell-cell fusion in CEM-174 cells

Activity141.2 μM

MethodIC50

RECORD: Rec_0340360 VERIFIED: YES