Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length200 amino acids

Chemical FormulaC1037H1556N226O298S9

DescriptionStandard

        IDDLAKVDYSLNSLPAVFQPFIDLDLKGIVYPAGNCSGPPYVAAPFTIPDQSDSMLYLAFSEYFFQTSSFAYYTAGAFNITIAEEVIKSGKLFYLFFFFFLQTCSYFNISTEIFGSIIPEVAKYSVTPYPVMLKLMATEIPIISLEQDSFTVEIQGSMEVFAVLPDSTPQSLFTMNIAANTSIALNIFDQKLMGSLCLNR
    

Molecular Weight22245.37 Da

Isoelectric Point (pI)4.11

Net Charge (pH 7.0)-11.25

Net Charge (pH 7.4) -11.55

Charge Density (pH 7.0) -0.0563

GRAVY Index0.43

Hydrophobic Moment 0.55

Boman Index0.29

Instability Index45.84

Aliphatic Index 96.10

Aromaticity 0.1550

Extinction Coeff. Reduced 16390.00

Extinction Coeff. Oxidized 16515.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8252.02

LogP -93.42

H-bond Donors 279.0

H-bond Acceptors 296.0

Rotatable Bonds 705.0

Heavy Atoms 1570.0

Ring Count 44.0

Amide Bonds 215.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0268299 VERIFIED: YES

Provenance & Taxonomy

OrganismEudyptula [Animal]

Tax ID37082

Structure & Mods

Configgene-encoded linear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria