Peptide Database

Peptide NameSLAY-screened peptide P727

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC107H162N38O27S3

DescriptionStandard

        TPYHCVHRPTRWQRCCRDPP
    

Molecular Weight2508.86 Da

Isoelectric Point (pI)9.21

Net Charge (pH 7.0)2.54

Net Charge (pH 7.4) 2.21

Charge Density (pH 7.0) 0.1271

GRAVY Index-1.49

Hydrophobic Moment 0.63

Boman Index-0.46

Instability Index59.80

Aliphatic Index 14.50

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1042.89

LogP -10.76

H-bond Donors 40.0

H-bond Acceptors 35.0

Rotatable Bonds 70.0

Heavy Atoms 175.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0193983 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/