Peptide Database

Peptide NameSLAY-screened peptide P4500

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H168N22O25S

DescriptionStandard

        PLLVPYAPCYTVAIPINLPK
    

Molecular Weight2182.67 Da

Isoelectric Point (pI)8.57

Net Charge (pH 7.0)0.95

Net Charge (pH 7.4) 0.87

Charge Density (pH 7.0) 0.0473

GRAVY Index0.81

Hydrophobic Moment 0.18

Boman Index0.42

Instability Index40.77

Aliphatic Index 136.50

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 696.87

LogP -1.15

H-bond Donors 23.0

H-bond Acceptors 27.0

Rotatable Bonds 59.0

Heavy Atoms 154.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0187904 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/