Peptide Database

Peptide NameSLAY-screened peptide P187

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC107H178N42O28S

DescriptionStandard

        HNFPCVYLARRRSSTRRGRVT
    

Molecular Weight2532.89 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)5.84

Net Charge (pH 7.4) 5.57

Charge Density (pH 7.0) 0.2779

GRAVY Index-0.99

Hydrophobic Moment 0.40

Boman Index-0.51

Instability Index115.88

Aliphatic Index 50.95

Aromaticity 0.0952

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1180.85

LogP -15.10

H-bond Donors 47.0

H-bond Acceptors 36.0

Rotatable Bonds 81.0

Heavy Atoms 178.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0155384 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/