Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2323H3758N608O656S16

DescriptionStandard

        MLALSLFLVLLAVASTTLSVNPGVTVRLTDKGLQYGKQLGIAAMQEKLKSIQIPDFSGSQRVSPIGKVKYSLSNIRLVNVGLPSSAVTLVPGTGVRLTIGNAFMNLHGNWRVKYLRVIKDSGSFDVNVNGLTISTTIVVKSDATGRPVVSNTNCVANVASAKVKFHGGASWLYNLFSKFINKALRNALQKQICPLVDKTVIGLNPKLQTLNVLAKVDKYAEIEYSMVSSPVISQSSLDLNLKGQFYNIGKHQEPPFIPAAFSLPSQNNNMLYMALSAFTANSAGFVYNKAGVLSLYITDDMVPKGSPFRLNTKTFGVFIPQIAKQYPGLMMKLLVRAEKSPTITFQPKNATAVATATVTAYAIQPNGTLSPLFVLNVESSVSADVYVRGLNIAGRLTLNQMKLSVGTSYVGQFQVGVLDSVLRMVLKVVVIPIVNVQLDKGYPLPALGKMNLVNPQLQIMKDYMLIGTDVNFTG
    

Molecular Weight51213.40 Da

Isoelectric Point (pI)9.90

Net Charge (pH 7.0)23.73

Net Charge (pH 7.4) 23.24

Charge Density (pH 7.0) 0.0501

GRAVY Index0.24

Hydrophobic Moment 0.83

Boman Index0.17

Instability Index31.89

Aliphatic Index 107.68

Aromaticity 0.0781

Extinction Coeff. Reduced 34840.00

Extinction Coeff. Oxidized 34965.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0267775 VERIFIED: NO

Provenance & Taxonomy

OrganismPoecilia mexicana [Bacterium]

FamilyBPI

Tax ID48701

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence