Peptide Database

Peptide NameSLAY-screened peptide P5235

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H141N25O32S3

DescriptionStandard

        HSPARGSCVDLYYSYCYYSC
    

Molecular Weight2337.56 Da

Isoelectric Point (pI)6.71

Net Charge (pH 7.0)-0.19

Net Charge (pH 7.4) -0.49

Charge Density (pH 7.0) -0.0093

GRAVY Index-0.28

Hydrophobic Moment 0.20

Boman Index0.05

Instability Index70.51

Aliphatic Index 39.00

Aromaticity 0.2500

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7575.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 917.38

LogP -9.33

H-bond Donors 37.0

H-bond Acceptors 36.0

Rotatable Bonds 66.0

Heavy Atoms 163.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0152031 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/