Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length174 amino acids

Chemical FormulaC879H1386N246O233S7

DescriptionStandard

        VAHEPMLLLAITDFVANSAAFTYFTAGALHRNISSHMLPRRFPLQLRTKSMGVFSPQLQKRYPDHPMELHLSARRQPLFSCRPDALHGSLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNKLGGTVSLKGLRDLSVPQVKRLENLLKFSLWLFGVPWANSECCPHPVP
    

Molecular Weight19352.37 Da

Isoelectric Point (pI)10.11

Net Charge (pH 7.0)9.32

Net Charge (pH 7.4) 8.69

Charge Density (pH 7.0) 0.0536

GRAVY Index0.01

Hydrophobic Moment 0.57

Boman Index0.08

Instability Index54.61

Aliphatic Index 93.62

Aromaticity 0.0862

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7553.18

LogP -79.28

H-bond Donors 262.0

H-bond Acceptors 256.0

Rotatable Bonds 615.0

Heavy Atoms 1365.0

Ring Count 40.0

Amide Bonds 186.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0095149 VERIFIED: NO

Provenance & Taxonomy

OrganismArenaria interpres (Ruddy turnstone) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria