Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length350 amino acids

Chemical FormulaC1726H2660N438O508S20

DescriptionStandard

        MEFHEGMAICFACRGSSVLHAEDPKFSPWHQVRKERILPETLEMFNDVEFPNTSVSLIPGTGIKLSVNEASAIVIHCFFVSSRSSGRLMVFISGVSIVAVASASQDETGRPMLLLESCQGKVHEVNIQLDETASFKSLYLESYDIFSLQGTVYPVGKVTEPPIKPAPFTLPETMDCMFYIGVSEYFFQSASLAYFTCGAFNASTLSSYFKVTTDTLGSILPTVADRYAEPLPVMMNIVATAAPVIHLHNASFRLELAASVEMLAVLPNSTTQSMFTLNIVSTPAVESIHRSTAAVLDQAKGLSCLASCLPVADQIAKWEAHNRCNSTHLPFFPSNWYSAVISSHYGWQPL
    

Molecular Weight38315.51 Da

Isoelectric Point (pI)5.43

Net Charge (pH 7.0)-10.58

Net Charge (pH 7.4) -11.56

Charge Density (pH 7.0) -0.0302

GRAVY Index0.21

Hydrophobic Moment 0.62

Boman Index0.19

Instability Index47.92

Aliphatic Index 88.89

Aromaticity 0.1000

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37400.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0220319 VERIFIED: NO

Provenance & Taxonomy

OrganismVaranus komodoensis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence