Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length89 amino acids

Chemical FormulaC446H725N137O129S8

DescriptionStandard

        MLQTRSSTLSGHNKLWFLTLAVLVVLAQTSPEGWFRTCFYGLGKCRRICRANEKKKERCGERTFCCLRETNSRLSHIPVTKDREKDESC
    

Molecular Weight10326.89 Da

Isoelectric Point (pI)9.46

Net Charge (pH 7.0)7.62

Net Charge (pH 7.4) 7.18

Charge Density (pH 7.0) 0.0856

GRAVY Index-0.53

Hydrophobic Moment 0.69

Boman Index-0.20

Instability Index60.29

Aliphatic Index 68.99

Aromaticity 0.0787

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4371.45

LogP -47.28

H-bond Donors 166.0

H-bond Acceptors 147.0

Rotatable Bonds 351.0

Heavy Atoms 720.0

Ring Count 13.0

Amide Bonds 93.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0120784 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyDefensin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q3V2L0/entry; https://bblserver.org.in/ampdb/