Peptide Database

Peptide NamePL2

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC138H191N37O38S

DescriptionStandard

        RSQKEGLHYTCSSHFPYSQYQFWK
    

Molecular Weight3008.28 Da

Isoelectric Point (pI)9.05

Net Charge (pH 7.0)1.92

Net Charge (pH 7.4) 1.59

Charge Density (pH 7.0) 0.0801

GRAVY Index-1.31

Hydrophobic Moment 0.38

Boman Index-0.19

Instability Index64.16

Aliphatic Index 16.25

Aromaticity 0.2500

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1239.33

LogP -11.82

H-bond Donors 45.0

H-bond Acceptors 43.0

Rotatable Bonds 94.0

Heavy Atoms 214.0

Ring Count 10.0

Amide Bonds 26.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0402563 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 YU2 | TZM-bl cells

Activity136±49 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 2 min; E. coli: 2 min

PaperPeptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. | Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA. | J Biol Chem. 2012 Apr 27;287(18):15076-86. | DOI:10.1074/jbc.M111.332361 | PMID:22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/

FIRST PREV 1 2 3 4

Showing 1 records on this page Ã‚Â· Page 4 of 4