‹ ›
MYP_022665
← PREVIOUS NEXT → BACK
Basic Information
PL2
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
24 amino acids
C138H191N37O38S
Standard
Sequence
RSQKEGLHYTCSSHFPYSQYQFWK
Physicochemical Analysis
3008.28 Da
9.05
1.92
1.59
0.0801
-1.31
0.38
-0.19
64.16
16.25
0.2500
9970.00
9970.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1239.33
-11.82
45.0
43.0
94.0
214.0
10.0
26.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0269407 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 HxB2
PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0295674 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 BaL26
PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0318332 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 NL4-3 | TZM-bl cells
103±37 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperPeptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. | Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA. | J Biol Chem. 2012 Apr 27;287(18):15076-86. | DOI:10.1074/jbc.M111.332361 | PMID:22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0348779 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0394856 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 HxB2:inhibition of virus infection in TZM-bl cells
89±31 μM
IC50
PaperPubMed PMID: 22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
FIRST PREV 1 2 3 4 NEXT LAST
Showing 5 records on this page · Page 3 of 4