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MYP_022665
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Basic Information
PL2
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
24 amino acids
C138H191N37O38S
Standard
Sequence
RSQKEGLHYTCSSHFPYSQYQFWK
Physicochemical Analysis
3008.28 Da
9.05
1.92
1.59
0.0801
-1.31
0.38
-0.19
64.16
16.25
0.2500
9970.00
9970.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1239.33
-11.82
45.0
43.0
94.0
214.0
10.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0136516 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 BaL26 | TZM-bl cells
138±36 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperPeptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. | Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA. | J Biol Chem. 2012 Apr 27;287(18):15076-86. | DOI:10.1074/jbc.M111.332361 | PMID:22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0144053 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0158589 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells
103±37 μM
IC50
PaperPubMed PMID: 22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0240009 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 YU2:inhibition of virus infection in TZM-bl cells
136±49 μM
IC50
PaperPubMed PMID: 22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0259603 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3
PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
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