Peptide Database

Peptide NameLL-37 (6-20)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC87H148N26O21

DescriptionStandard

        FRKSKEKIGKEFKRI
    

Molecular Weight1894.27 Da

Isoelectric Point (pI)10.56

Net Charge (pH 7.0)4.76

Net Charge (pH 7.4) 4.55

Charge Density (pH 7.0) 0.3174

GRAVY Index-1.47

Hydrophobic Moment 0.71

Boman Index-0.57

Instability Index9.73

Aliphatic Index 52.00

Aromaticity 0.1333

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 819.45

LogP -5.71

H-bond Donors 30.0

H-bond Acceptors 26.0

Rotatable Bonds 72.0

Heavy Atoms 134.0

Ring Count 2.0

Amide Bonds 14.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0134812 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetMycobacterium smegmatis mc2-155

Activity2400 μg/mL

MethodMIC

RECORD: Rec_0405636 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

TargetMurine macrophage cells J774A.1 (50% Cell death at 11226 microg/ml

Activity774 μg/mL

MethodHemolysis