Peptide Database

Peptide NameGranulysin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC185H310N74O55S3

DescriptionStandard

        TQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQG
    

Molecular Weight4547.10 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)8.38

Net Charge (pH 7.4) 8.16

Charge Density (pH 7.0) 0.2205

GRAVY Index-1.18

Hydrophobic Moment 0.86

Boman Index-0.56

Instability Index71.60

Aliphatic Index 35.79

Aromaticity 0.0789

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2209.63

LogP -32.06

H-bond Donors 87.0

H-bond Acceptors 67.0

Rotatable Bonds 153.0

Heavy Atoms 317.0

Ring Count 4.0

Amide Bonds 42.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0354596 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGranulysin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antimycobacterial Antibacterial

TargetMycobacterium tuberculosis H37Rv ATCC 25623

Activity30 μM

MethodMIC