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MYP_022490
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Basic Information
D366/369A
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
11 amino acids
C57H93N15O15
Standard
Sequence
WNSLKIANLAV
Physicochemical Analysis
1228.44 Da
8.75
0.76
0.55
0.0690
0.66
0.25
0.31
4.87
150.91
0.0909
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
502.54
-3.32
17.0
16.0
39.0
87.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0182720 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
Sup-T1
43 %
Inhibition
PaperMechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/
RECORD: Rec_0211651 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1
PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/
RECORD: Rec_0287385 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 45.5%, C 54.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0343798 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
0.1 μM
% inhibition
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperMechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. | Hayouka Z, Levin A, Maes M, Hadas E, Shalev DE, Volsky DJ, Loyter A, Friedler A. | Biochem Biophys Res Commun. 2010 Apr 2;394(2):260-5. | DOI:10.1016/j.bbrc.2010.02.100 | PMID:20171172 PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/
RECORD: Rec_0408986 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1[40-50% IN activity = 19.5 microM
PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/