Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length200 amino acids

Chemical FormulaC1037H1555N225O299S9

DescriptionStandard

        IDDLAKVDYSLNSLPAVFQPFIDLDLKGIVYPAGNCSGPPYVAAPFTIPDQSDSMLYLAFSEYFFQTSSFAYYTAGAFNITIAEEVIKSGKLFYLFFFFFLQTCSYFNISTEIFGSIIPEVAKYSVTPYPVMLKLMATEIPIISLEQDSFTVEIEGSMEVFAVLPDSTPQSLFTMNIAANTSIALNIFDQKLMGSLCLNR
    

Molecular Weight22246.35 Da

Isoelectric Point (pI)4.09

Net Charge (pH 7.0)-12.25

Net Charge (pH 7.4) -12.55

Charge Density (pH 7.0) -0.0612

GRAVY Index0.43

Hydrophobic Moment 0.55

Boman Index0.29

Instability Index48.03

Aliphatic Index 96.10

Aromaticity 0.1550

Extinction Coeff. Reduced 16390.00

Extinction Coeff. Oxidized 16515.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8246.23

LogP -92.82

H-bond Donors 279.0

H-bond Acceptors 296.0

Rotatable Bonds 705.0

Heavy Atoms 1570.0

Ring Count 44.0

Amide Bonds 214.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0064902 VERIFIED: NO

Provenance & Taxonomy

OrganismEudyptula minor [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence