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MYP_022406
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Basic Information
Peptide 4(lactoferrin 441-454)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
14 amino acids
C70H114N20O23
Standard
Sequence
KANEGLTWNSLKDK
Physicochemical Analysis
1603.77 Da
8.50
0.76
0.55
0.0544
-1.36
0.13
-0.28
-4.76
62.86
0.0714
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
736.71
-7.98
25.0
24.0
56.0
113.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009015 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-H1N1 Replication inhibition
A/Parma/24/09 H1N1 | MDCK cells
0.00005±0.00025 μM
EC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperLactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors. | Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P. | Sci Rep. 2017 Sep 6;7(1):10593. | DOI:10.1038/s41598-017-10492-x | PMID:28878220 PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0043484 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-H1N1 Replication inhibition
A/Roma-ISS/02/08 H1N1 | MDCK cells
0.000001±0.00000015 μM
EC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperLactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors. | Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P. | Sci Rep. 2017 Sep 6;7(1):10593. | DOI:10.1038/s41598-017-10492-x | PMID:28878220 PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0112243 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
A/Parma0/5/06 H3N2:inhibition of virus replication in MDCK cells
0.000001±0.00036 μM
EC50
PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0243601 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Virus:A/Roma-ISS/02/08 H1N1:inhibition of virus replication in MDCK cells
0.000001±0 μM
EC50
PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0255037 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
A/Parma/24/09 H1N1:inhibition of virus replication in MDCK cells
0.00005±0.00025 μM
EC50
PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
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