Peptide Database

Peptide NameP16 [TNF α (75–94)]

Function Ontology

Anticancer

Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H176N28O29

DescriptionStandard

        LLTHTISRIAVSYQTKVNLL
    

Molecular Weight2270.67 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)1.85

Net Charge (pH 7.4) 1.59

Charge Density (pH 7.0) 0.0923

GRAVY Index0.54

Hydrophobic Moment 0.49

Boman Index0.17

Instability Index11.12

Aliphatic Index 151.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 940.38

LogP -8.21

H-bond Donors 34.0

H-bond Acceptors 32.0

Rotatable Bonds 75.0

Heavy Atoms 160.0

Ring Count 2.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0092383 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Anticancer Anti-angiogenic

Activity0.0172±0.00195 μM

MethodIC50

Half-LifeBALB/c mice plasma (Dose i/v injected), in vivo; 345.6 s

RECORD: Rec_0248675 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyTNF alpha-derived

Tax ID32630