Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length501 amino acids

Chemical FormulaC2466H3906N666O693S17

DescriptionStandard

        MPGSPPRPRGFGGSGGQNMAREPDKALTRATLVVLATLGTAVIATTNPGVVARITQKGLDYACQQGVAVLQKELEKITIPTFSGSFKIKHLGKGHYSFHSMAIRGFQLPVSQIKLAPSEGLDLSIANANVKISGKWKARKNFIKTSGNFDLSVEGVSISAVLKLGFDPASGHCTVSCSRCNNHINSVRVHISGSSLGWLINLFHEKMESSLRNRMTGEICKVVTSSVSSKLQRYLETMPVTTRIDHVAGINYSLVAPPTATTDSLDGQLKGEFFRWGHPSPPPFAPPPLAFPSDHDRMVYLGISNYFFNTAGFVYQQAGVLNLTVTDNVIPKESKFRLTTDVFGILIPQVAKMFPNMKVQLVFWASSPPHLTVHPEGLVLTPTLDAQAFAVLPNSSLAPLFVLRLSMNISVTVGATPDRLVGQLSLNRLLLELKHSDIGPFSVEVLQALMNYVVPIAVIPKVNERLQEGFPLPMPNNVQLFNLVLQSHQNFLLFGADVRYG
    

Molecular Weight54516.54 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)13.70

Net Charge (pH 7.4) 12.62

Charge Density (pH 7.0) 0.0273

GRAVY Index0.08

Hydrophobic Moment 0.71

Boman Index0.13

Instability Index37.53

Aliphatic Index 96.27

Aromaticity 0.0798

Extinction Coeff. Reduced 35410.00

Extinction Coeff. Oxidized 35660.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0276399 VERIFIED: NO

Provenance & Taxonomy

OrganismFelis catus [Animal]

FamilyBPI

Tax ID9685

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence