Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2438H3884N650O684S24

DescriptionStandard

        MREDMARGLHDASRWASLLVLVAVGTTVTAATNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSGSFKIKLLGKGRYSFYSMDIREFQLPSCQISMVPSVGLKFSISNANIKISGKWKARKRFIKTSGNFDLSVEGVSISADLKLGSNSTSGKPTVTCSSCSSHINRVHVRISKSRVGWLIRLFRKKIESTLRNKLNSQVCEKVTSSVSSELQPYFQTLPVMTKIDAVAGINYGLVAPPTTMAETLDVQMKGEFYSQNHHNPPPFAPPVMEFPAAHDHMVYLGLSDYFFNTAGLVYQQAGVLKMTLRDDMIPKESKFRLTTKFFGNFLPEVAKMFPNMKIQIHVSASTPPQLSVQPTGLTFYPAVDVQTFAVLPNSSLASLFLIGMHTTASMEVGAKSDRLVGKLKVDRLLLELKHSNIGPFPVELMQSIMNYIVPTFVLPRVNEKLQKGCPLPMPARVQVYNMVLQPYQNFLLFGADVVYK
    

Molecular Weight54014.42 Da

Isoelectric Point (pI)9.74

Net Charge (pH 7.0)23.34

Net Charge (pH 7.4) 22.43

Charge Density (pH 7.0) 0.0479

GRAVY Index-0.03

Hydrophobic Moment 0.77

Boman Index0.08

Instability Index36.59

Aliphatic Index 90.02

Aromaticity 0.0883

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0022892 VERIFIED: NO

Provenance & Taxonomy

OrganismRhinopithecus roxellana [Animal]

FamilyBPI/LBP

Tax ID61622

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria