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MYP_022318
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Basic Information
LL-37 (17-29) [K25R]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C80H135N27O17
Standard
Sequence
FKRIVQRIRDFLR
Physicochemical Analysis
1747.10 Da
12.00
3.76
3.56
0.2892
-0.48
0.98
-0.47
25.23
112.31
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
766.53
-4.58
29.0
21.0
61.0
124.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0167954 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
μg/ml
200 μg/mL
Cytotoxicity
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0168330 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
12.5 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0221973 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0304193 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
56 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0336215 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
56 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
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