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MYP_022301
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Basic Information
trans-[3,12]-dicarba α-conotoxin RgIA
Miscellaneous
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GCXSDPRCRYRXR
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0255937 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
mixed L/D or residue-modified peptide [Mixed]
None
None
Agl=Carbabridge [C2 unsaturated] (half)
Bio-Activity Profile
Nicotinic acetylcholine receptor antagonist Ion channel inhibitor Toxin
PaperConoServer: updated content, knowledge, and discovery tools in the conopeptide database; Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets. DOI:10.1021/jm501126u PMID22058133;25393758 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22058133/
RECORD: Rec_0432637 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
α-conotoxin RgIA analogue
Structure & Mods
linear peptide [Linear]
mixed L/D or residue-modified peptide [Mixed]
Agl=Carbabridge [C2 unsaturated] (half)
Bio-Activity Profile
Nicotinic acetylcholine receptor antagonist Ion channel inhibitor Toxin
rat α9α10 nicotinic acetylcholine receptor
1.15 μM
IC50
PaperDicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets. DOI:10.1021/jm501126u PMID25393758
RECORD: Rec_0432638 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
α-conotoxin RgIA analogue
Structure & Mods
linear peptide [Linear]
mixed L/D or residue-modified peptide [Mixed]
Agl=Carbabridge [C2 unsaturated] (half)
Bio-Activity Profile
Nicotinic acetylcholine receptor antagonist Ion channel inhibitor Toxin
rat α7 nicotinic acetylcholine receptor
3.95 μM
IC50
PaperDicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets. DOI:10.1021/jm501126u PMID25393758