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MYP_022284
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Basic Information
Trialysin (26-53)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
27 amino acids
C126H232N34O30S2
Standard
Sequence
VSAVAKVAMKKGAALLKKMGVKISPLK
Physicochemical Analysis
2767.53 Da
10.78
6.73
6.51
0.2491
0.53
0.54
0.13
18.04
119.26
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1033.73
-6.93
36.0
39.0
100.0
192.0
1.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0071523 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Trypanosoma cruzi Y
41.7 μg/mL
LC50
PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0100206 VERIFIED: YES
Provenance & Taxonomy
Triatoma infestans [Animal]
Trialysin
30076
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Cytolytic Antiparasitic Anti-Trypanosoma cruzi
Trypanosoma cruzi
15 μM
LC50; Microscopy (Surviving parasites counted by Neubauer hemocytometer)
PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0103223 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human erythrocytes
>2500 μg/mL
Hemolysis
PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0161743 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Hemolytic
Human erythrocytes
900 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/16460023/ PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0254652 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 44.4%, E 0.0%, T 37.0%, C 18.5% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiparasitic Toxic Antimicrobial Cytotoxic Antitrypanosomal
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
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