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MYP_022244
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Basic Information
Sub3 (Bac2A variant through three amino acids substitution)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Standard
12 amino acids
C74H133N31O13
Standard
Sequence
RRWRIVVIRVRR
Physicochemical Analysis
1665.05 Da
12.00
5.76
5.56
0.4800
-0.53
0.46
-0.70
145.29
137.50
0.0833
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
770.61
-4.91
32.0
19.0
56.0
118.0
2.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0157901 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa
2 μg/mL
MIC
1 h (in 25% aqueous mouse serum,Sub3 was relatively stable for a medium-sized peptide)
PaperHigh-throughput generation of small antibacterial peptides with improved activity. Nat Biotechnol. 2005 Aug;23(8):1008-1012. doi: 10.1038/nbt1113. PMID: 16041366. PMID16041366 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16041366/
RECORD: Rec_0159405 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
0.5 μg/mL
MIC
PMID31616307 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31616307/
RECORD: Rec_0185468 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
4 μM
MIC
PaperHigh-throughput generation of small antibacterial peptides with improved activity PMID16041366 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16041366/
RECORD: Rec_0191511 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli UB1005
2 μg/mL
MIC
PMID31616307 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31616307/
RECORD: Rec_0214961 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
2 μg/mL
MIC
PMID16041366 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16041366/
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