Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length432 amino acids

Chemical FormulaC2129H3376N534O624S17

DescriptionStandard

        MSLCCWFILLAFIPEALSTDPGVIVKLTDKGLEYGRQLGMAVIQKQLLTIKVADISGSESVSPIGSVEYRLSNMHIVDVGLPKSEVDLVPGSGVRLFIGNAFIMSFVLKDSGSFDLNVNGLTISTSIAIKSDETGRPAVSTVDCVASISSVRVIFHGGASWLYNLFTSFIDRSLRNAIQTQVCPSVANAVSQLNSQLKTLNVVAQVDQYAEIDYSMVSSPMVSQSSIDLSLKGEFYNVGKHQEPPFSPTPFSLSSQLSNMLYFGMSAFTANSAAFVYNSAGALSLYITDDMIPHTSLFRLNTMTFGAFIPQVAKLFPGLLMKLLVQTVKTPVITFEPNNATIQATGTVTAYAILPNTTLSPLFVLNLETSVSTKVFVREMRLAGAVTLNKMDLTLRTSYVREFQVKSLDNFLQVVLKGVVIPKVNGEFLYFT
    

Molecular Weight46981.89 Da

Isoelectric Point (pI)6.44

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.72

Charge Density (pH 7.0) -0.0027

GRAVY Index0.35

Hydrophobic Moment 0.79

Boman Index0.20

Instability Index30.94

Aliphatic Index 104.40

Aromaticity 0.0926

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0106401 VERIFIED: NO

Provenance & Taxonomy

OrganismMonopterus albus [Animal]

FamilyBPI

Tax ID43700

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence