Peptide Database

Peptide Nameiso-Atrial natriuretic peptide-45

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length45 amino acids

Chemical FormulaC208H346N72O68S3

DescriptionStandard

        SQDSAERIQERLRNSKMAHSSSCFGQKIDRIGAVSRLGCDGLRQF
    

Molecular Weight5039.61 Da

Isoelectric Point (pI)9.49

Net Charge (pH 7.0)2.53

Net Charge (pH 7.4) 2.24

Charge Density (pH 7.0) 0.0563

GRAVY Index-0.74

Hydrophobic Moment 0.75

Boman Index-0.28

Instability Index67.82

Aliphatic Index 65.11

Aromaticity 0.0444

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2339.40

LogP -31.81

H-bond Donors 86.0

H-bond Acceptors 75.0

Rotatable Bonds 178.0

Heavy Atoms 351.0

Ring Count 3.0

Amide Bonds 49.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0040938 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

Tax ID10116

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide23-39

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0052402 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyNatriuretic peptide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide23-39

Bio-Activity Profile

Function

Natriuretic Vasodilator

MethodRadioimmunoassay

Half-LifeMale Wistar rats plasma (Dose i/p injected), in vivo; 164.3 s