Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length505 amino acids

Chemical FormulaC2504H3933N635O725S27

DescriptionStandard

        MRPRRLGNCQSRKFPRPATHEIMTGRMLLYLTAGCLLTCLAHGTQPAIKVILSEKGLQYVKEMGAEWLLQNLGSASPPDVHGKLSLSLGTVYYSIMGMAVTYCEFAEPSVEFYEDVTGFKAVISGLYIQVKGAWSASYGIFEDGGAFELVIRDLEVDLLLGLGMDADGQPSFRCAACGASVGSAGLNLIDASWIIEQFIDEELIRSTIEEKICPMITERLDELEYRLAALGATFQVNHLLAVDLPLTSYPVVNSSCLSLSLKGMFHRPDSPVDPPFEPQPFSLDGQPGYMLSLGLSEYTTNSASHAYFVSGSLQLLITDSMIPPSSPLHLNTNSFGPFVPKLPKMFPDMEMQLQVFALEAPEFMFRSGVVRMDVHGAIKAFVVRPDGTFIFLFRLNLESTFSGKFRMANEKLTGAIALENLYLTLDSSEVGEVQTDALKIAIKFGIKLSGLPRLNAKLAKGIDLPTMQHAHLTNLVLEVEEGFISVLSDAEIKLREAKVGTPWMV
    

Molecular Weight55398.59 Da

Isoelectric Point (pI)5.15

Net Charge (pH 7.0)-15.62

Net Charge (pH 7.4) -16.59

Charge Density (pH 7.0) -0.0309

GRAVY Index0.16

Hydrophobic Moment 0.69

Boman Index0.16

Instability Index34.54

Aliphatic Index 98.50

Aromaticity 0.0891

Extinction Coeff. Reduced 42860.00

Extinction Coeff. Oxidized 43360.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0120237 VERIFIED: NO

Provenance & Taxonomy

OrganismGadus morhua [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence