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MYP_022135
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Basic Information
Leu-enkephalin
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Neuropeptide activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Standard
5 amino acids
C28H37N5O7
Standard
Sequence
YGGFL
Physicochemical Analysis
555.62 Da
5.52
-0.24
-0.45
-0.0482
0.90
0.23
0.69
15.70
78.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.95
-0.16
7.0
7.0
15.0
40.0
2.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0362003 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Opioid peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
Neuropeptide Analgesic
Human plasma mixed with AS-1397
TLC
17.2 ± 0.9 min
PaperIn vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure
RECORD: Rec_0387668 VERIFIED: YES
Provenance & Taxonomy
Aplysia californica [Animal]
Opioid
6500
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID8257438 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8257438/
RECORD: Rec_0402184 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Leu-enkephalin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Receptor modulation
Experimental: 21.2±1.1 minute; /1272 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Leu-enkephalin (Sus scrofa): PMID 6123953##12444298 PMID6123953;12444298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6123953/
RECORD: Rec_0412761 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
opioid neuropeptide precursor family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide opioid neuropeptide precursor family Growth factor signaling Hormone Neuropeptide signaling
PaperPDB 5E3A structural record; X-ray; 2.05 A; chain B; residues 1-5
RECORD: Rec_0424140 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Leu-enkephalin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Receptor modulation
Experimental: 21.2±1.1 minute; /1272 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Leu-enkephalin (Bos taurus): PMID 9074507##12444298 PMID9074507;12444298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9074507/
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