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MYP_022135
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Basic Information
Leu-enkephalin
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Neuropeptide activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Standard
5 amino acids
C28H37N5O7
Standard
Sequence
YGGFL
Physicochemical Analysis
555.62 Da
5.52
-0.24
-0.45
-0.0482
0.90
0.23
0.69
15.70
78.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.95
-0.16
7.0
7.0
15.0
40.0
2.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198184 VERIFIED: YES
Provenance & Taxonomy
Felis catus [Animal]
Leu-enkephalin
9685
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Receptor modulation
Experimental: 21.2±1.1 minute; /1272 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Leu-enkephalin (Felis catus): PMID 8719703##12444298 PMID8719703;12444298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8719703/
RECORD: Rec_0199164 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Opioid
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID8257438 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8257438/
RECORD: Rec_0210707 VERIFIED: YES
Provenance & Taxonomy
Aplysia californica [Animal]
Leu-enkephalin
6500
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Experimental: 21.2±1.1 minute; /1272 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Leu-enkephalin (Aplysia californica): PMID 8257438##12444298 PMID8257438;12444298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8257438/
RECORD: Rec_0238118 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Leu-enkephalin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Receptor modulation
Experimental: 21.2±1.1 minute; /1272 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Leu-enkephalin (Rattus norvegicus): PMID 3858883##12444298 PMID3858883;12444298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3858883/
RECORD: Rec_0273819 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Enkephalin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Thiomethylene bond replacement between residue 4-5
Bio-Activity Profile
Analgesic
HPLC
Human serum, in vitro; 18900 s
PMID4034413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4034413/
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