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MYP_022135
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Basic Information
Leu-enkephalin
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Neuropeptide activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Standard
5 amino acids
C28H37N5O7
Standard
Sequence
YGGFL
Physicochemical Analysis
555.62 Da
5.52
-0.24
-0.45
-0.0482
0.90
0.23
0.69
15.70
78.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.95
-0.16
7.0
7.0
15.0
40.0
2.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0150974 VERIFIED: NO
Provenance & Taxonomy
Sus scrofa [Animal] [Animal]; Bos taurus [Animal] [Animal]; Homo sapiens [Animal] [Animal]; Tupaia belangeri [Animal] [Animal]; Taeniopygia guttata [Animal]
Enkephalin
9823;9913;9606;37347;59729
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
RECORD: Rec_0163747 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Enkephalin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Agonist
opioid receptor
PaperHughes J., Smith T. W., Kosterlitz H. W., Fothergill L. A., Morgan B. A., Morris H. R.. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature, 258, 577-579, 1975.
RECORD: Rec_0174431 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Enkephalin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Physiological regulation Behavior regulation
TLC
Human plasma mixed with drug Sulpiride, in vitro; 714 s
PaperIn vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure PMID12444298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12444298/
RECORD: Rec_0181066 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Enkephalin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Thiomethylene bond replacement between residue 1-2
Bio-Activity Profile
Analgesic
HPLC
Human serum, in vitro; 5640 s
PMID4034413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4034413/
RECORD: Rec_0195654 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Enkephalin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Nociception regulating peptide
HPLC
Nasal administration to Male Sprague Dawley derived rats, in vivo; 1434 s
PMID7714746 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7714746/
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