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MYP_022135
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Basic Information
Leu-enkephalin
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Neuropeptide activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Standard
5 amino acids
C28H37N5O7
Standard
Sequence
YGGFL
Physicochemical Analysis
555.62 Da
5.52
-0.24
-0.45
-0.0482
0.90
0.23
0.69
15.70
78.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.95
-0.16
7.0
7.0
15.0
40.0
2.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0115236 VERIFIED: YES
Provenance & Taxonomy
Cavia porcellus [Animal]
Leu-Enkephalin
10141
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator
Experimental: 21.2±1.1 minute; /1272 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Leu-Enkephalin (Cavia porcellus): PMID 6265943##12444298 PMID6265943;12444298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6265943/
RECORD: Rec_0115553 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Opioid
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID8257438 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8257438/
RECORD: Rec_0135716 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Enkephalin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Analgesic
HPLC
Human serum, in vitro; 882 s
PMID4034413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4034413/
RECORD: Rec_0139506 VERIFIED: YES
Provenance & Taxonomy
Felis catus [Animal]
Opioid
9685
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID8257438 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8257438/
RECORD: Rec_0144368 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Opioid peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
Neuropeptide Analgesic
Human plasma mixed with promethazine
TLC
17.1 ± 1.0 min
PaperIn vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure
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