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MYP_022135
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Basic Information
Leu-enkephalin
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Neuropeptide activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Standard
5 amino acids
C28H37N5O7
Standard
Sequence
YGGFL
Physicochemical Analysis
555.62 Da
5.52
-0.24
-0.45
-0.0482
0.90
0.23
0.69
15.70
78.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.95
-0.16
7.0
7.0
15.0
40.0
2.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0038369 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Enkephalin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Neurotransmitter
HPLC and LC/ITMS
Bacterial strain B-9 cell culture, in vitro; <300 s
PMID22186872 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22186872/
RECORD: Rec_0043726 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Opioid
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID8257438 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8257438/
RECORD: Rec_0049913 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Enkephalin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Thiomethylene bond replacement between residue 2-3
Bio-Activity Profile
Analgesic
HPLC
Human serum, in vitro; 4764 s
PMID4034413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4034413/
RECORD: Rec_0109586 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication Drug Delivery Vehicle Blood-Brain Barrier
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0113458 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Enkephalin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperMoosmann B., Behl C.. Secretory peptide hormones are biochemical antioxidants: Structure-activity relationship. Mol. Pharmacol., 61 (2002), 260-268.
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