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MYP_022100
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Basic Information
Esculentin (1-21)[L14l,S17s]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Wound healing
Standard
21 amino acids
C102H181N27O25
Standard
Sequence
GIFSKLAGKKIKNLLISGLKG
Physicochemical Analysis
2185.69 Da
10.60
4.76
4.54
0.2264
0.34
0.59
0.17
-18.78
134.76
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
858.97
-6.29
30.0
30.0
81.0
154.0
1.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011882 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
l=D-Leu; s=D-Ser
Bio-Activity Profile
Antimicrobial Anticancer
A549
10 %
Cytotoxicity
PaperPubMed PMID: 32722535 PMID32722535 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32722535/
RECORD: Rec_0025707 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
A549
50 %
Cytotoxicity
PaperPubMed PMID: 32722535 PMID32722535 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32722535/
RECORD: Rec_0026553 VERIFIED: YES
Provenance & Taxonomy
Pelophylax lessonae [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Refer PubMed ID: 23503622 [P. aeruginosa ATCC 27853
8 μM
MIC
PMID31144441;26162435;23503622 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31144441/
RECORD: Rec_0057499 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
8292;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa PAO1 / ATCC 15692
24, 12, 6, 1.5 μM
Total countable CFUs
RECORD: Rec_0079675 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Sheep erythrocytes
10 %
Hemolysis
PaperPubMed PMID: 32722535 PMID32722535 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32722535/
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