Peptide Database

Peptide NameP-52

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC156H261N41O51

DescriptionStandard

        WEQKIEELLKKAEEQQKKNEEELKKLEK
    

Molecular Weight3526.99 Da

Isoelectric Point (pI)5.36

Net Charge (pH 7.0)-1.22

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0437

GRAVY Index-2.00

Hydrophobic Moment 0.63

Boman Index-0.53

Instability Index80.41

Aliphatic Index 73.21

Aromaticity 0.0357

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1581.03

LogP -11.05

H-bond Donors 51.0

H-bond Acceptors 50.0

Rotatable Bonds 137.0

Heavy Atoms 248.0

Ring Count 2.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0348381 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral Cytotoxic

TargetHIV-1; TZM-bl cells

MethodHIV-1 pseudovirus / fusion inhibition assay

PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. J Virol. 2018 Sep 26;92(20):e01088-18. doi: 10.1128/JVI.01088-18. PMID: 30089693. PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/

RECORD: Rec_0356858 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermC18 stearic-acid conjugation

Other ModsC18 stearic-acid conjugated lipopeptide

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 CH040.c/2625; TZM-bl cells

Activity22.67±5.55 pM

MethodIC50

RECORD: Rec_0390227 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermC16 palmitic-acid conjugation

Other ModsC16 palmitic-acid conjugated lipopeptide

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 LAI; TZM-bl cells

Activity12.22±0.93 pM

MethodIC50

RECORD: Rec_0403032 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 JR-CSF; TZM-bl cells

Activity0.0019±0.0004 μM

MethodIC50

PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. J Virol. 2018 Sep 26;92(20):e01088-18. doi: 10.1128/JVI.01088-18. PMID: 30089693. PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/

RECORD: Rec_0416599 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermC16 palmitic-acid conjugation

Other ModsC16 palmitic-acid conjugated lipopeptide

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 89.6; TZM-bl cells

Activity17.49±2.05 pM

MethodIC50

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