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MYP_021997
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Basic Information
P-52
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
28 amino acids
C156H261N41O51
Standard
Sequence
WEQKIEELLKKAEEQQKKNEEELKKLEK
Physicochemical Analysis
3526.99 Da
5.36
-1.22
-1.45
-0.0437
-2.00
0.63
-0.53
80.41
73.21
0.0357
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1581.03
-11.05
51.0
50.0
137.0
248.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002064 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 pseudovirus panel (multiple subtypes); TZM-bl cells
0.020541 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | Chong H, Zhu Y, Yu D, He Y. | J Virol. 2018 Sep 26;92(20):e01088-18. | DOI:10.1128/JVI.01088-18 | PMID:30089693 PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
RECORD: Rec_0006090 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
C18 stearic-acid conjugation
C18 stearic-acid conjugated lipopeptide
Bio-Activity Profile
Antiviral
HIV-1 R3A; TZM-bl cells
5.67±0.85 pM
IC50
PMID30716118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716118/
RECORD: Rec_0010161 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
C16 palmitic-acid conjugation
C16 palmitic-acid conjugated lipopeptide
Bio-Activity Profile
Antiviral
HIV-1 JR-CSF; TZM-bl cells
8.02±3.59 pM
IC50
PMID30716118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716118/
RECORD: Rec_0017328 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
C18 stearic-acid conjugation
C18 stearic-acid conjugated lipopeptide
Bio-Activity Profile
Antiviral
HIV-1 89.6; TZM-bl cells
5.27±0.3 pM
IC50
PMID30716118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716118/
RECORD: Rec_0030150 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
C16 palmitic-acid conjugation
C16 palmitic-acid conjugated lipopeptide
Bio-Activity Profile
Antiviral
HIV-1 THRO.c/2626; TZM-bl cells
27.12±4.61 pM
IC50
PMID30716118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30716118/
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