Peptide Database

Peptide Namecompound 6

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus

Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor

Standard Statusnot Standard

Sequence Length12 amino acids

Chemical Formula-

Descriptioncontains X representing unresolved or non-standard residue

        YAIIXYNKYXNC
    

Molecular Weight0.00 Da

Isoelectric Point (pI)0.00

Net Charge (pH 7.0)0.00

GRAVY Index0.00

Boman Index0.00

Instability Index0.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0322184 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermThioether-acyl moiety (-S-Ac-)(forms a macrocycle through the side chain of the underlined cysteine residue)

C-TermAmidation

Other ModsThe 'X' at position 5 indicates N-methyl-4-O-methyl-tyrosine, position 10 indicates N-methyl-leucine.; Thioether-acyl moiety (-S-Ac-)(forms a macrocycle through the side chain of the underlined cysteine residue)

Bio-Activity Profile

Function

Antiviral Anti-WNV Entry inhibition

TargetWest Nile virus | Huh-7 cells

Activity20 μM

MethodIC50

PaperDe Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease. | Nitsche C, Passioura T, Varava P, Mahawaththa MC, Leuthold MM, Klein CD, Suga H, Otting G. | ACS Med Chem Lett. 2019 Jan 4;10(2):168-174. | DOI:10.1021/acsmedchemlett.8b00535 | PMID:30783498 PMID30783498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30783498/

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