Peptide Database

Peptide NameCaerin 1.1 mod 10(Caerin 1.1 [S4K;H12K,H16K,H24K])

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC124H224N30O29

DescriptionStandard

        GLLKVLGSVAKKVLPKVVPVIAEKL
    

Molecular Weight2599.29 Da

Isoelectric Point (pI)10.18

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.1503

GRAVY Index0.98

Hydrophobic Moment 0.62

Boman Index0.29

Instability Index15.73

Aliphatic Index 171.20

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 931.77

LogP -2.94

H-bond Donors 31.0

H-bond Acceptors 33.0

Rotatable Bonds 89.0

Heavy Atoms 183.0

Ring Count 2.0

Amide Bonds 24.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0287966 VERIFIED: YES

Provenance & Taxonomy

OrganismSythetic construct [Animal]

FamilyCaerin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHuman immunodeficiency virus (HIV):inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells

Activity4 μM

MethodIC50

RECORD: Rec_0351843 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCaerin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV PsV

RECORD: Rec_0408992 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCaerin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV Release inhibition

TargetHuman immunodeficiency virus (HIV) | T cells

Activity4 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of HIV infection by caerin 1 antimicrobial peptides. | VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA. | Peptides. 2015 Sep;71:296-303. | DOI:10.1016/j.peptides.2015.05.004 | PMID:26026377 PMID26026377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/