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MYP_021905
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Basic Information
Defensin-C (AaeDefC; Insects, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
40 amino acids
C169H279N59O52S6
Standard
Sequence
ATCDLLSGFGVGDSACAAHCIARRNRGGYCNAKKVCVCRN
Physicochemical Analysis
4161.78 Da
8.94
3.82
3.49
0.0956
0.03
0.50
-0.05
41.44
66.00
0.0500
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1811.33
-25.32
71.0
63.0
137.0
286.0
3.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0342591 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0355078 VERIFIED: YES
Provenance & Taxonomy
Aedes aegypti [Animal]
Defensin
7159
Structure & Mods
Disulfide-stabilized peptide [Linear]
noncanonical stereochemical modification [Modified]
three disulfide bonds
Bio-Activity Profile
Antimicrobial Antifungal
Fusarium culmorum
50-100 μM
MIC
PaperUse of Defensins to Develop Eco-Friendly Alternatives to Synthetic Fungicides to Control Phytopathogenic Fungi and Their Mycotoxins PMID35330231 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35330231/
RECORD: Rec_0382292 VERIFIED: YES
Provenance & Taxonomy
Aedes aegypti [Animal]
AaeDefC
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperInsect Biochem Mol Biol. 1995 Jul;25(7):867-73 | http://www.ncbi.nlm.nih.gov/pubmed/7633471 PMID7633471 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7633471/
RECORD: Rec_0396464 VERIFIED: YES
Provenance & Taxonomy
Aedes aegypti [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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