Peptide Database

Peptide NameUnnamed

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC161H258N46O59

DescriptionStandard

        FNVALDQVFESIENSQALVDQSNRILSSAEKGNTG
    

Molecular Weight3782.04 Da

Isoelectric Point (pI)4.18

Net Charge (pH 7.0)-3.23

Net Charge (pH 7.4) -3.44

Charge Density (pH 7.0) -0.0923

GRAVY Index-0.34

Hydrophobic Moment 0.60

Boman Index-0.01

Instability Index40.68

Aliphatic Index 89.14

Aromaticity 0.0571

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1750.15

LogP -23.54

H-bond Donors 58.0

H-bond Acceptors 56.0

Rotatable Bonds 130.0

Heavy Atoms 266.0

Ring Count 2.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0210206 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0250852 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-MPV Fusion inhibition

TargetHuman Metapneumovirus(hMPV) | LLC-MK2 cells

Activity1.52 μM

MethodIC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min

PaperIdentification and evaluation of a highly effective fusion inhibitor for human metapneumovirus. | Deffrasnes C, Hamelin ME, Prince GA, Boivin G. | Antimicrob Agents Chemother. 2008 Jan;52(1):279-87. | DOI:10.1128/AAC.00793-07 | PMID:17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/

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