Peptide Database

Peptide NameNL15

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC62H95N15O11

DescriptionStandard

        WKGPAKLLWK
    

Molecular Weight1226.51 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.2757

GRAVY Index-0.61

Hydrophobic Moment 0.52

Boman Index0.05

Instability Index34.96

Aliphatic Index 88.00

Aromaticity 0.2000

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 426.07

LogP 0.85

H-bond Donors 15.0

H-bond Acceptors 14.0

Rotatable Bonds 38.0

Heavy Atoms 88.0

Ring Count 5.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0230061 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Replication inhibition

TargetHIV-1

Activity1000 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperSequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme. | Li HY, Zawahir Z, Song LD, Long YQ, Neamati N. | J Med Chem. 2006 Jul 27;49(15):4477-86. | DOI:10.1021/jm060307u | PMID:16854053 PMID16854053 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16854053/

RECORD: Rec_0312307 VERIFIED: YES