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MYP_021844
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Basic Information
Brevinin-1SN1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
24 amino acids
C117H199N33O27S2
Standard
Sequence
FLPAVLKVAAHILPTAICAISRRC
Physicochemical Analysis
2564.17 Da
9.70
2.83
2.54
0.1178
1.22
0.53
0.31
81.27
142.50
0.0417
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
934.00
-5.65
35.0
33.0
79.0
179.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001948 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans ATCC 10231
>400 μM
MIC
PaperIdentification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae).
RECORD: Rec_0002292 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
200 μM
Hemolysis
PMID24055160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24055160/
RECORD: Rec_0027784 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial
PaperY. Ma et al. / Genomics 95 (2010) 66-71. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0043328 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Psychrobacter faecalis X29
25 μM
MIC
PMID24055160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24055160/
RECORD: Rec_0052491 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic Anti-Gram-positive
Staphylococcus aureus
3.1 μM
MIC
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