Peptide Database

Peptide Name[Arg-1,Arg0,D-Ala2]deltorphin II

Function Ontology

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Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC50H77N15O13

DescriptionStandard

        RRYAFEVVG
    

Molecular Weight1096.24 Da

Isoelectric Point (pI)8.75

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0847

GRAVY Index-0.13

Hydrophobic Moment 0.41

Boman Index-0.12

Instability Index81.03

Aliphatic Index 75.56

Aromaticity 0.2222

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 477.45

LogP -3.18

H-bond Donors 18.0

H-bond Acceptors 14.0

Rotatable Bonds 34.0

Heavy Atoms 78.0

Ring Count 2.0

Amide Bonds 8.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0016185 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermAmidation

Other ModsD-Ala2 (parent deltorphin numbering); N-terminal Arg-Arg extension

Bio-Activity Profile

Function

Blood-brain barrier permeability Opioid peptide

Targetprimary bovine brain microvessel endothelial cells

MethodBMEC in vitro blood-brain barrier permeability assay