Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length396 amino acids

Chemical FormulaC1962H3060N486O577S21

DescriptionStandard

        MLPSVMVVFAILSCTRAENPAVQVTLTDKWLQYVKHVGAGWIQDKLEHITFPDISGDVDILIGHVYYTLSGIRITKCDLPEPVLEFFQSTGLKTSIVGLNAALVGNWRTSFGIIHDSGSFDMAIFSVSLTSVVQLGRDPDGHLSITSIGCEPQVGNVAIQFHGGASFMFQPFVDHYKDKIVSVIQSNICPNVQTAIDDLESHLQAMSISYDVNEVLTVELPLTSPPVISGDDVNLGLKGEFYSIETHQEPPFVAQPFVLPKEPNYMMSVGLSEFMLNSASFGYFSAGNLQVLVNDSMIPPKSPIHLNTTSMGMFIPQLPKLYPDMLMNLQVYATEAPMLSLQMDVVEVGAQLGAKAFAIEPNGTQVPLFTLSVETRLSGKMWIVDEKLKANAMLDK
    

Molecular Weight43361.56 Da

Isoelectric Point (pI)4.76

Net Charge (pH 7.0)-18.62

Net Charge (pH 7.4) -19.48

Charge Density (pH 7.0) -0.0470

GRAVY Index0.20

Hydrophobic Moment 0.58

Boman Index0.21

Instability Index40.55

Aliphatic Index 99.37

Aromaticity 0.0859

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37150.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0082818 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius furzeri [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria